Oxsoralen

Oxsoralen (also known as Methoxsalen) is a drug used in the treatment of psoriasis, eczema, vitiligo, and some cutaneous lymphomas in conjunction with exposing the skin to sunlight. It belongs to a group of medications known as psoralens.

History

Oxsoralen was first synthesized in 1947 by Albert Kligman, a dermatologist at the University of Pennsylvania. It was initially used in the treatment of skin conditions such as psoriasis and eczema.

Mechanism of Action

Oxsoralen works by intercalating into the DNA of skin cells, forming covalent bonds with the DNA upon exposure to ultraviolet light. This process, known as photochemotherapy or PUVA therapy, leads to the death of the abnormal skin cells, thereby reducing the symptoms of the skin condition.

Side Effects

Common side effects of Oxsoralen include nausea, headache, and burning of the skin. Long-term use of Oxsoralen can increase the risk of skin cancer due to the DNA damage it causes.

Precautions

Patients using Oxsoralen should avoid exposure to sunlight for 24 hours after taking the medication to prevent severe burns. It is also recommended to wear sunglasses for 24 hours after taking Oxsoralen to protect the eyes from potential damage.

See Also

• Psoralen
• PUVA therapy
• Psoriasis
• Eczema
• Vitiligo

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