P-type calcium channel

P-type calcium channel is a type of voltage-gated calcium channel that plays a crucial role in neuronal function. Named for their purification from Purkinje cells, P-type calcium channels are found in the brain and other tissues, where they contribute to the regulation of calcium levels and participate in various cellular processes.

Function

P-type calcium channels are activated by changes in the membrane potential and allow the passage of calcium ions into the cell. This influx of calcium triggers a variety of cellular responses, including neurotransmitter release, muscle contraction, and gene expression. In neurons, P-type calcium channels are particularly important for the initiation of action potentials and the propagation of electrical signals.

Structure

Like other voltage-gated calcium channels, P-type calcium channels are composed of several subunits. The main, or α1, subunit forms the pore through which calcium ions pass and is responsible for the channel's voltage-sensing properties. Other subunits, including the β, γ, and δ subunits, modulate the channel's function and help anchor it in the cell membrane.

Clinical significance

Mutations in the genes encoding P-type calcium channels can lead to a variety of neurological disorders. For example, mutations in the CACNA1A gene, which encodes the α1 subunit of the P/Q-type calcium channel (a subtype of P-type calcium channel), have been associated with Familial Hemiplegic Migraine, Episodic Ataxia Type 2, and Spinocerebellar Ataxia Type 6.

See also

• Voltage-gated ion channel
• Calcium channel blocker
• Calcium signaling

References

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