P2RY8

P2RY8 is a gene that encodes a protein belonging to the family of G-protein coupled receptors (GPCRs). These receptors are involved in various physiological processes and are known for their role in signal transduction across cell membranes.

Function

The P2RY8 gene is part of the purinergic receptor family, which is activated by nucleotides such as ATP and ADP. These receptors play a crucial role in the regulation of immune response, inflammation, and cell proliferation.

Clinical Significance

Mutations or alterations in the P2RY8 gene have been associated with certain types of leukemia, particularly in cases of acute lymphoblastic leukemia (ALL). The gene is often involved in chromosomal translocations that can lead to the development of cancer.

Expression

P2RY8 is expressed in various tissues, with significant expression in the immune system, particularly in lymphocytes. Its expression pattern suggests a role in the regulation of immune cell function and development.

Research

Ongoing research is focused on understanding the precise mechanisms by which P2RY8 influences cell signaling and its potential as a therapeutic target in cancer treatment. Studies are also exploring its role in other diseases involving the immune system.

See Also

• G-protein coupled receptor
• Purinergic signaling
• Leukemia

External Links

• P2RY8 Gene - NCBI
• P2RY8 Gene - GeneCards

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