PAIP1

Ideogram human chromosome 5

PAIP1

PAIP1 (Poly(A) binding protein interacting protein 1) is a protein-coding gene that plays a crucial role in the regulation of mRNA translation. It is involved in the interaction with Poly(A) binding protein (PABP) and eukaryotic translation initiation factor 4G (eIF4G), which are essential components of the translation initiation complex.

Function

PAIP1 functions as a translational regulator by promoting the association of PABP with the translation initiation complex, thereby enhancing translation efficiency. It also plays a role in mRNA stability and localization within the cell.

Structure

The PAIP1 gene is located on chromosome 19 in humans and encodes a protein consisting of multiple domains that mediate its interactions with other translation factors. These domains include the PAM2 motif, which binds to PABP, and the MLLE domain, which interacts with eIF4G.

Role in Translation

PAIP1 is essential for the efficient translation of mRNAs by facilitating the circularization of the mRNA molecule through its interactions with PABP and eIF4G. This circularization promotes ribosome recruitment and enhances translation initiation.

Clinical Significance

Mutations in the PAIP1 gene have been associated with certain neurological disorders and developmental abnormalities. Dysregulation of PAIP1 expression can lead to defects in mRNA translation and protein synthesis, which may contribute to disease pathogenesis.

Interactions

PAIP1 interacts with several other proteins involved in translation, including PABP, eIF4G, and eIF3. These interactions are crucial for the formation of the translation initiation complex and the regulation of protein synthesis.