PANORAMIC trial

A clinical trial investigating COVID-19 treatments

Logo of the PANORAMIC trial

The PANORAMIC trial (Platform Adaptive trial of NOvel antiviRals for eArly treatMent of covid-19 In the Community) is a significant clinical trial conducted in the United Kingdom. It aims to evaluate the effectiveness of antiviral medications in treating COVID-19 in the community setting. This trial is particularly focused on individuals who are at higher risk of complications from COVID-19.

Background

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to a global health crisis, necessitating the rapid development and deployment of effective treatments. While vaccines have been a primary tool in controlling the spread of the virus, there remains a critical need for effective therapeutic options, especially for those who contract the virus despite vaccination or are unable to be vaccinated.

Objectives

The primary objective of the PANORAMIC trial is to assess the efficacy of novel antiviral treatments in reducing the severity of COVID-19 symptoms and preventing hospitalizations. The trial also aims to gather data on the safety and tolerability of these treatments in a diverse population.

Design

The PANORAMIC trial is designed as a platform adaptive trial, which allows for the evaluation of multiple treatments simultaneously. This design is particularly advantageous in rapidly evolving situations like the COVID-19 pandemic, as it enables the trial to adapt to new information and incorporate additional treatments as they become available.

Eligibility Criteria

Participants in the PANORAMIC trial are typically individuals who have tested positive for COVID-19 and are at higher risk of developing severe illness. This includes older adults and those with underlying health conditions. The trial is conducted in the community setting, allowing for a broad and inclusive participant base.

Treatments Evaluated

The trial evaluates several antiviral medications, including those that have shown promise in early studies. These treatments are administered to participants shortly after a positive COVID-19 test to assess their impact on disease progression.

Significance

The PANORAMIC trial is one of the largest community-based trials for COVID-19 treatments. Its findings are expected to inform public health strategies and treatment guidelines, particularly for managing COVID-19 in non-hospitalized patients.

Related pages

• COVID-19 pandemic
• Antiviral drug
• Clinical trial
• SARS-CoV-2