PAQR7
PAQR7[edit | edit source]
PAQR7 (Progestin and AdipoQ Receptor family member 7) is a protein that in humans is encoded by the PAQR7 gene. This protein is part of the progestin and adipoQ receptor (PAQR) family, which is involved in various cellular processes, including metabolism and reproductive functions.
Structure[edit | edit source]
PAQR7 is a member of the membrane receptor family characterized by a seven-transmembrane domain structure. This structure is similar to that of G protein-coupled receptors (GPCRs), although PAQR7 and its family members are not classical GPCRs. The protein is embedded in the cell membrane, allowing it to interact with extracellular signals and transmit them into the cell.
Function[edit | edit source]
PAQR7 is primarily known for its role in mediating the effects of progestins, which are a group of steroid hormones. These hormones are crucial for regulating the menstrual cycle, maintaining pregnancy, and influencing other reproductive processes. PAQR7 is thought to act as a membrane-bound receptor for these hormones, facilitating rapid non-genomic signaling pathways.
In addition to its role in reproductive biology, PAQR7 has been implicated in metabolic processes. It is believed to interact with adiponectin, a hormone involved in regulating glucose levels and fatty acid breakdown. This interaction suggests a potential role for PAQR7 in metabolic homeostasis and energy balance.
Expression[edit | edit source]
The expression of PAQR7 is tissue-specific, with high levels found in reproductive tissues such as the ovaries and uterus. It is also expressed in other tissues, including the brain and adipose tissue, indicating a broader physiological role.
Clinical Significance[edit | edit source]
Alterations in PAQR7 expression or function have been associated with various clinical conditions. For example, dysregulation of PAQR7 may contribute to reproductive disorders, such as infertility or polycystic ovary syndrome (PCOS). Additionally, given its role in metabolism, PAQR7 may be involved in metabolic disorders like obesity and type 2 diabetes.
Research is ongoing to better understand the precise mechanisms by which PAQR7 influences these conditions and to explore its potential as a therapeutic target.
Also see[edit | edit source]
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