PAR1 (gene)

Ideogram human chromosome 15

PAR1 (gene)

PAR1 is a gene that encodes a protein known as Protease-Activated Receptor 1. This gene is located on chromosome 5 in humans and is involved in various physiological processes. Protease-Activated Receptor 1 is a member of the G-protein coupled receptor family and plays a crucial role in mediating cellular responses to protease activity.

Function

The protein encoded by the PAR1 gene is activated by cleavage of its N-terminus by serine proteases. Once activated, Protease-Activated Receptor 1 can initiate intracellular signaling cascades that regulate processes such as inflammation, thrombosis, and cell proliferation. Activation of PAR1 has been implicated in various diseases, including cardiovascular disorders and cancer.

Clinical Significance

Mutations in the PAR1 gene have been associated with an increased risk of thrombosis and cardiovascular events. Additionally, dysregulation of Protease-Activated Receptor 1 signaling has been linked to the progression of certain types of cancer. Understanding the role of PAR1 in disease pathogenesis may lead to the development of novel therapeutic strategies targeting this gene.

Interactions

Protease-Activated Receptor 1 interacts with various proteins and signaling molecules to modulate its activity. Some of the known interactors of PAR1 include coagulation factors, proteases, and G-proteins. These interactions play a crucial role in regulating the downstream signaling pathways activated by PAR1.