PCID2

PCID2 is a protein that in humans is encoded by the PCID2 gene. This gene is located on chromosome 13 and is involved in various cellular processes, including the regulation of the cell cycle and the maintenance of genomic stability.

Function

PCID2 is a component of the TREX-2 complex, which is involved in the export of mRNA from the nucleus to the cytoplasm. The TREX-2 complex plays a crucial role in coupling transcription and mRNA export, ensuring that mRNA is properly processed and transported to the cytoplasm for translation.

Structure

The PCID2 protein contains several conserved domains that are important for its function. These include the PCI domain, which is involved in protein-protein interactions, and the MPN domain, which is implicated in the regulation of ubiquitin-like proteins.

Interactions

PCID2 interacts with several other proteins within the TREX-2 complex, including GANP, DSS1, and ENY2. These interactions are essential for the proper functioning of the TREX-2 complex and the efficient export of mRNA.

Clinical Significance

Mutations or dysregulation of the PCID2 gene can lead to various diseases, including cancer. The role of PCID2 in maintaining genomic stability makes it a potential target for cancer therapy.

Research

Ongoing research is focused on understanding the detailed mechanisms by which PCID2 and the TREX-2 complex regulate mRNA export and how dysregulation of these processes contributes to disease.

See Also

• TREX-2 complex
• mRNA export
• Genomic stability
• Cell cycle