PDE5 inhibitor
PDE5 inhibitors are a class of drugs that are primarily used to treat erectile dysfunction and certain cardiovascular conditions. They work by blocking the enzyme phosphodiesterase type 5 (PDE5), which plays a crucial role in regulating blood flow to the penis and lungs.
Mechanism of Action[edit | edit source]
PDE5 inhibitors work by blocking the enzyme phosphodiesterase type 5 (PDE5). This enzyme is responsible for breaking down cyclic guanosine monophosphate (cGMP), a substance that promotes relaxation and dilation of blood vessels. By inhibiting PDE5, these drugs increase the levels of cGMP, leading to improved blood flow.
Uses[edit | edit source]
PDE5 inhibitors are primarily used to treat erectile dysfunction (ED). They can also be used to treat pulmonary arterial hypertension (PAH), a type of high blood pressure that affects the arteries in the lungs and the right side of the heart.
Side Effects[edit | edit source]
Common side effects of PDE5 inhibitors include headaches, flushing, upset stomach, and changes in vision. In rare cases, they can cause a painful erection that lasts longer than four hours, a condition known as priapism.
Examples[edit | edit source]
Examples of PDE5 inhibitors include sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra).
See Also[edit | edit source]
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