PGRMC2

Ideogram human chromosome 4

PGRMC2

PGRMC2 (Progesterone Receptor Membrane Component 2) is a protein-coding gene that plays a crucial role in various cellular processes. It is located on chromosome Xq22.1 and encodes a protein that is part of the membrane-associated progesterone receptor (MAPR) family.

Function

PGRMC2 is involved in diverse cellular functions, including cell proliferation, apoptosis, and steroid hormone signaling. It has been implicated in the regulation of mitochondrial function and cholesterol metabolism. Additionally, PGRMC2 has been linked to cancer progression and drug resistance in certain types of cancer.

Structure

The PGRMC2 protein consists of multiple domains, including a transmembrane domain and a cytoplasmic domain. These domains enable PGRMC2 to interact with various cellular components and participate in signaling pathways.

Clinical Significance

Mutations in the PGRMC2 gene have been associated with certain diseases, such as cancer and metabolic disorders. Understanding the role of PGRMC2 in these conditions may lead to the development of targeted therapies and diagnostic tools.

Interactions

PGRMC2 interacts with a variety of proteins and molecules within the cell, modulating their activity and influencing cellular processes. These interactions are essential for the proper functioning of PGRMC2 in different cellular contexts.