PK-11195
PK-11195 is a synthetic molecule of the isoquinoline carboxamide family. It was first synthesized in the 1980s by the French pharmaceutical company Servier, and is most commonly used in scientific research as a reference ligand for the peripheral benzodiazepine receptor, also known as the translocator protein (TSPO).
History[edit | edit source]
PK-11195 was first synthesized in the 1980s by the French pharmaceutical company Servier. It was initially developed as a potential therapeutic agent for a variety of conditions, including anxiety disorders and epilepsy. However, its clinical development was discontinued due to its poor pharmacokinetic properties and lack of efficacy in clinical trials.
Pharmacology[edit | edit source]
PK-11195 is a selective ligand for the peripheral benzodiazepine receptor, also known as the translocator protein (TSPO). It binds to the TSPO with high affinity and specificity, and is often used in scientific research as a reference ligand for this protein.
Uses[edit | edit source]
Although PK-11195 is not used clinically, it is widely used in scientific research. Its primary use is as a reference ligand for the TSPO in studies investigating the role of this protein in various physiological and pathological processes. These include studies on neuroinflammation, neurodegeneration, and the response of the brain to injury and disease.
See also[edit | edit source]
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