PLD4

PLD4 (Phospholipase D4) is a gene that encodes a member of the phospholipase D family of enzymes. These enzymes are involved in the hydrolysis of phospholipids to produce phosphatidic acid and a free head group. PLD4 is implicated in various biological processes, including immune response and cell signaling.

Function

PLD4 is primarily expressed in the immune system, particularly in macrophages and dendritic cells. It plays a role in the regulation of immune cell function and has been associated with autoimmune diseases. The enzyme activity of PLD4 contributes to the modulation of inflammatory responses and cellular communication.

Clinical Significance

Mutations in the PLD4 gene have been linked to certain autoimmune disorders, such as systemic lupus erythematosus (SLE). Research suggests that PLD4 may be involved in the pathogenesis of these conditions by affecting the immune system's ability to regulate itself.

Research

Studies on PLD4 have focused on its role in immune regulation and its potential as a therapeutic target for autoimmune diseases. Animal models have been used to investigate the effects of PLD4 deficiency and overexpression, providing insights into its function in immune homeostasis.

See Also

• Phospholipase D
• Immune system
• Autoimmune disease

External Links

• PLD4 Gene - NCBI
• PLD4 Gene - GeneCards