PNU-120,596

PNU-120,596 is a pharmacological compound that acts as a positive allosteric modulator at alpha7 nicotinic acetylcholine receptors. It is used in scientific research to investigate the role of these receptors in the brain.

Chemistry

PNU-120,596 is a synthetic compound. Its chemical structure is distinct from that of other known alpha7 nicotinic acetylcholine receptor modulators. The compound is typically prepared in a laboratory setting.

Pharmacology

PNU-120,596 acts as a positive allosteric modulator at alpha7 nicotinic acetylcholine receptors. This means that it enhances the activity of these receptors in the presence of their natural ligand, acetylcholine. The compound does not activate the receptors directly, but instead increases their response to acetylcholine.

Research Applications

PNU-120,596 is used in scientific research to investigate the role of alpha7 nicotinic acetylcholine receptors in the brain. These receptors are thought to be involved in a variety of neurological and psychiatric conditions, including schizophrenia, Alzheimer's disease, and cognitive impairment. By studying the effects of PNU-120,596, researchers can gain insights into the function of these receptors and their potential as therapeutic targets.

Safety and Toxicity

As a research compound, PNU-120,596 is not intended for human consumption. Its safety and toxicity in humans have not been thoroughly studied. In animal studies, the compound has been shown to have a relatively low toxicity profile.

See Also

• Allosteric modulator
• Nicotinic acetylcholine receptor
• Neuropharmacology