PPP1CB

Protein PPP1CB PDB 1s70

Protein Phosphatase 1 catalytic subunit beta (PPP1CB) is an enzyme that in humans is encoded by the PPP1CB gene. It is a catalytic subunit of protein phosphatase 1 (PP1), a key enzyme involved in the regulation of various cellular processes.

Function

PPP1CB is a serine/threonine phosphatase that plays a crucial role in the dephosphorylation of a wide range of proteins. It is involved in the regulation of cell division, glycogen metabolism, muscle contraction, and neuronal signaling pathways.

Structure

The PPP1CB protein consists of multiple domains, including a catalytic domain responsible for its phosphatase activity. It forms a complex with regulatory subunits to achieve substrate specificity and regulate its activity.

Clinical Significance

Mutations in the PPP1CB gene have been associated with certain genetic disorders and diseases, highlighting the importance of this enzyme in maintaining normal cellular function. Dysregulation of PPP1CB activity has been linked to conditions such as cancer, neurodegenerative diseases, and metabolic disorders.

Interactions

PPP1CB interacts with various regulatory subunits and targeting proteins to form specific holoenzymes that target distinct substrates within the cell. These interactions are crucial for the precise regulation of cellular processes.

References

- Infobox protein - Reflist