PRKCQ
PRKCQ (Protein Kinase C Theta) is a protein that in humans is encoded by the PRKCQ gene. This protein is a member of the Protein Kinase C (PKC) family of serine/threonine protein kinases which can be activated by calcium and the second messenger diacylglycerol.
Function[edit | edit source]
PRKCQ protein is involved in diverse cellular signaling pathways including the B-cell receptor (BCR) signalosome, the Fc epsilon RI-mediated mast cell activation, the T cell receptor (TCR) signaling, and the NF-kappaB signaling pathway. The protein is predominantly expressed in hematopoietic cells.
Clinical significance[edit | edit source]
Mutations in PRKCQ have been associated with autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis.
Etymology[edit | edit source]
The term PRKCQ is an abbreviation for Protein Kinase C Theta. The term 'Protein Kinase' refers to a type of enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). 'C' refers to the specific subtype of this enzyme family, and 'Theta' is a further classification within this subtype.
Related terms[edit | edit source]
- Protein Kinase C
- Gene
- Protein
- Calcium
- Diacylglycerol
- B-cell receptor
- Fc epsilon RI
- T cell receptor
- NF-kappaB
- Hematopoietic cells
- Systemic lupus erythematosus
- Rheumatoid arthritis
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Contributors: Prab R. Tumpati, MD
