PTPRCAP

Ideogram human chromosome 11

PTPRCAP

Protein tyrosine phosphatase receptor type C-associated protein (PTPRCAP) is a protein that in humans is encoded by the PTPRCAP gene. PTPRCAP is a member of the protein tyrosine phosphatase (PTP) family. This gene encodes a protein that is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

Function

PTPRCAP is a protein that interacts with the cytoplasmic domain of receptor protein tyrosine phosphatase type C (PTPRC) and is involved in the regulation of PTPRC activity. PTPRC, also known as CD45, is a transmembrane protein tyrosine phosphatase that is present on the surface of all nucleated hematopoietic cells. The interaction between PTPRC and PTPRCAP plays a role in the regulation of T-cell receptor signaling and T-cell activation.

Clinical Significance

Mutations in the PTPRCAP gene have been associated with certain types of cancer, including colorectal cancer. Studies have shown that alterations in PTPRCAP expression levels can impact cell proliferation and migration, suggesting a potential role for PTPRCAP in tumorigenesis.

Interactions

PTPRCAP has been shown to interact with PTPRC, as well as other proteins involved in signaling pathways. These interactions are important for the regulation of cellular processes and the maintenance of normal cell function.