PUM3

PUM3 (Pumilio RNA-binding family member 3) is a protein that in humans is encoded by the PUM3 gene. This protein is part of the Pumilio family of RNA-binding proteins that play a critical role in the regulation of gene expression. PUM3, like other members of its family, is involved in the post-transcriptional regulation of gene expression, primarily by binding to specific sequences in the 3' untranslated regions (3' UTRs) of target mRNAs, leading to their translational repression or degradation.

Function

PUM3 functions by binding to the specific nucleotide sequences known as Pumilio-binding elements (PBEs) located in the 3' UTRs of target mRNAs. This binding is facilitated through its Pumilio homology domain (PUM-HD), a conserved region that is characteristic of the Pumilio family of proteins. Through its interaction with target mRNAs, PUM3 plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis. The precise mechanisms through which PUM3 exerts its effects are complex and involve interactions with other protein factors and regulatory elements within the cell.

Clinical Significance

Alterations in the expression or function of PUM3 have been implicated in several human diseases, although the full extent of its involvement is still under investigation. Given its role in the regulation of gene expression, dysregulation of PUM3 activity could potentially contribute to the pathogenesis of cancer, neurological disorders, and other conditions where aberrant gene expression is a factor. Research into PUM3 and its associated pathways may offer insights into new therapeutic strategies for these diseases.

Gene

The PUM3 gene is located on chromosome 15 in humans. It encodes the PUM3 protein, which is expressed in various tissues throughout the body, indicating its broad role in cellular function and gene regulation.

See Also

• RNA-binding protein
• Gene expression
• Post-transcriptional regulation
• 3' untranslated region
• Pumilio homology domain