Globus pallidus
(Redirected from Pallidal)
Globus Pallidus is a subcortical structure of the brain, specifically a part of the basal ganglia. It plays a significant role in the regulation of voluntary movement. It is divided into two parts: the Globus Pallidus Internus (GPi) and the Globus Pallidus Externus (GPe).
Anatomy[edit | edit source]
The Globus Pallidus is located in the basal ganglia, which is a group of nuclei in the brain associated with control of voluntary motor movements, procedural learning, habit learning, eye movements, cognition, and emotion. The Globus Pallidus is divided into two parts: the Globus Pallidus Internus (GPi) and the Globus Pallidus Externus (GPe). These two parts have different functions and anatomical connections.
Function[edit | edit source]
The Globus Pallidus is involved in the regulation of voluntary movement. It receives input from the striatum and sends output to a number of different areas in the brain, including the thalamus and the subthalamic nucleus. The GPi and GPe have different roles in this process. The GPi sends inhibitory signals to the thalamus, which in turn sends signals to the motor cortex to initiate movement. The GPe, on the other hand, sends inhibitory signals to the subthalamic nucleus and the striatum, helping to regulate the activity of these areas.
Clinical Significance[edit | edit source]
Abnormalities in the Globus Pallidus can lead to a number of movement disorders, including Parkinson's disease and Huntington's disease. In Parkinson's disease, there is a loss of dopamine-producing cells in the striatum, which leads to overactivity of the GPi and underactivity of the GPe. This results in an imbalance in the regulation of movement, leading to the characteristic symptoms of the disease. In Huntington's disease, there is a loss of cells in the GPe, leading to overactivity of the GPi and underactivity of the striatum. This also results in an imbalance in the regulation of movement, leading to the characteristic symptoms of the disease.
See Also[edit | edit source]
| Globus pallidus Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
