Pancreaticobiliary maljunction

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Pancreaticobiliary maljunction
Synonyms PBM
Pronounce N/A
Specialty N/A
Symptoms Abdominal pain, jaundice, pancreatitis, cholangitis
Complications Biliary cancer, pancreatic cancer
Onset Usually in childhood or adulthood
Duration Chronic
Types N/A
Causes Congenital anomaly
Risks Biliary tract cancer, pancreatic cancer
Diagnosis Magnetic resonance cholangiopancreatography (MRCP), Endoscopic retrograde cholangiopancreatography (ERCP)
Differential diagnosis Choledochal cyst, biliary atresia
Prevention N/A
Treatment Surgical intervention, endoscopic therapy
Medication Analgesics, antibiotics for infections
Prognosis N/A
Frequency Rare
Deaths Related to complications such as cancer


Pancreaticobiliary maljunction (PBM) is a rare congenital anomaly characterized by a union of the pancreatic and biliary ducts located outside the duodenal wall. This condition is associated with an increased risk of biliary tract cancer and gallbladder cancer.

Anatomy[edit | edit source]

The pancreas and biliary tract are two separate systems in the body that aid in digestion. The pancreas produces enzymes that help break down food, while the biliary tract produces bile that helps the body absorb fats. In individuals with PBM, these two systems are connected, which can lead to various health complications.

Pathophysiology[edit | edit source]

In PBM, the junction of the pancreatic and biliary ducts is located outside the duodenal wall, usually within the head of the pancreas. This abnormal junction allows pancreatic juice to reflux into the biliary tract, leading to inflammation, increased pressure, and potential for malignancy.

Symptoms[edit | edit source]

Symptoms of PBM can vary greatly depending on the individual and the severity of the condition. Some individuals may experience no symptoms, while others may experience abdominal pain, jaundice, or recurrent pancreatitis.

Diagnosis[edit | edit source]

Diagnosis of PBM is typically made through imaging studies such as magnetic resonance cholangiopancreatography (MRCP), endoscopic retrograde cholangiopancreatography (ERCP), or ultrasound. These imaging studies can help visualize the pancreatic and biliary ducts and identify any abnormalities.

Treatment[edit | edit source]

Treatment for PBM typically involves surgery to correct the abnormal junction of the pancreatic and biliary ducts. This can help prevent complications such as biliary tract cancer and gallbladder cancer.

See also[edit | edit source]

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Contributors: Prab R. Tumpati, MD