Pancreozymin

Pancreozymin is a hormone that stimulates the release of pancreatic enzymes and the contraction of the gallbladder. It is also known as cholecystokinin (CCK) and was discovered by Ivy and Oldberg in 1928.

Function

Pancreozymin is secreted by the I-cells in the lining of the duodenum in response to a meal. It stimulates the release of both enzymes from the pancreas and bile from the gallbladder. The enzymes aid in the digestion of food, while the bile helps to emulsify fats.

Structure

The structure of pancreozymin is a peptide hormone. It is composed of a chain of amino acids. The exact structure can vary, with different forms having different numbers of amino acids.

Clinical significance

Abnormal levels of pancreozymin can lead to a number of medical conditions. High levels can cause pancreatitis, while low levels can result in poor digestion and malnutrition. It is also involved in the feeling of satiety, and thus can play a role in conditions such as obesity and anorexia.

History

Pancreozymin was first discovered by Ivy and Oldberg in 1928. They found that it stimulated the secretion of pancreatic enzymes, and named it after this function. Later, it was found to also stimulate the contraction of the gallbladder, and was given the additional name of cholecystokinin.

See also

• Digestive system
• Hormone
• Pancreas
• Gallbladder

References

Pancreozymin Resources
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