Pangamic acid

Pangamic Acid, often referred to as vitamin B15, is a term used to describe a variety of substances that contain dimethylglycine (DMG) and gluconic acid. Despite its initial classification as a vitamin, subsequent research has failed to confirm essential vitamin qualities or definitive physiological benefits in humans. The compound was first isolated in the 1950s by Dr. Ernst T. Krebs and his son, who claimed it had various health benefits, including improving cardiovascular health, enhancing liver function, and acting as an antioxidant. However, these claims lack substantial scientific backing, and the use of pangamic acid as a dietary supplement remains controversial.

Composition and Sources

Pangamic acid is not a single compound but rather a mixture that primarily includes dimethylglycine and gluconic acid. Dimethylglycine is a derivative of the amino acid glycine and is naturally present in small amounts in the body and in certain foods, such as grains and liver. Gluconic acid is a compound derived from glucose. Commercial supplements labeled as pangamic acid may vary significantly in their actual composition.

Claimed Benefits

Proponents of pangamic acid have attributed a wide range of health benefits to its use, including:

• Enhancing oxygen utilization and athletic performance
• Detoxifying the body, particularly the liver
• Acting as an antioxidant
• Reducing symptoms of conditions like asthma, rheumatism, and autism

However, these claims are not supported by rigorous scientific evidence. Research on pangamic acid is limited, and existing studies have not conclusively demonstrated its efficacy for these purported health benefits.

Safety and Regulation

The safety of pangamic acid supplements has been a subject of debate. In the United States, the Food and Drug Administration (FDA) has questioned the safety of these supplements and has taken action against companies making unfounded health claims. The FDA does not recognize pangamic acid as a vitamin or as a substance with proven health benefits, leading to restrictions on its sale and marketing.

Conclusion

While pangamic acid was once touted as a beneficial health supplement, the lack of scientific evidence supporting its efficacy and safety concerns have led to skepticism and regulatory scrutiny. Individuals considering the use of pangamic acid supplements should consult healthcare professionals and consider the current scientific consensus, which does not support its use for health enhancement.