Pattern recognition receptor
Pattern recognition receptors (PRRs) are a primitive part of the immune system. They are proteins that recognize molecules that are broadly shared by pathogens but distinguishable from host molecules, collectively referred to as pathogen-associated molecular patterns (PAMPs). They are also known to detect damage-associated molecular patterns (DAMPs) that are associated with cell damage.
Function[edit | edit source]
PRRs play a crucial role in the proper function of the innate immune system. They are germline-encoded host sensors, which detect molecules typical for the pathogens. They are proteins expressed by cells of the innate immune system to identify two classes of molecules: PAMPs and DAMPs present in pathogens or cellular debris respectively.
Types[edit | edit source]
There are several types of PRRs. These include:
- Toll-like receptors (TLRs)
- NOD-like receptors (NLRs)
- RIG-I-like receptors (RLRs)
- C-type lectin receptors (CLRs)
- AIM2-like receptors (ALRs)
Role in disease[edit | edit source]
PRRs play a significant role in the pathogenesis of many diseases, including cancer, autoimmune diseases, and infectious diseases. They can also contribute to sepsis and inflammatory diseases.
See also[edit | edit source]
References[edit | edit source]
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