Pempidine
An article about the drug Pempidine
Pempidine | |
---|---|
![]() | |
INN | |
Drug class | |
Routes of administration | |
Pregnancy category | |
Bioavailability | |
Metabolism | |
Elimination half-life | |
Excretion | |
Legal status | |
CAS Number | |
PubChem | |
DrugBank | |
ChemSpider | |
KEGG |
Pempidine is a ganglionic blocker that was historically used as an antihypertensive agent. It is a member of the piperidine class of compounds and functions by inhibiting the transmission of nerve impulses in the autonomic nervous system.
Chemical structure and properties[edit | edit source]
Pempidine is a piperidine derivative with the chemical formula C10H19N. It is characterized by a six-membered ring containing five carbon atoms and one nitrogen atom. The structure of pempidine allows it to interact with nicotinic acetylcholine receptors in the autonomic ganglia, leading to its pharmacological effects.
Pharmacology[edit | edit source]
Pempidine acts as a ganglionic blocker, which means it inhibits the transmission of nerve impulses in the autonomic nervous system. This action results in a decrease in blood pressure, making it useful in the treatment of hypertension. However, due to its broad effects on the autonomic nervous system, it can cause a range of side effects, limiting its clinical use.
Medical uses[edit | edit source]
Historically, pempidine was used as an antihypertensive agent. It was one of the early drugs used to manage high blood pressure by blocking the transmission of nerve signals in the autonomic ganglia. However, with the development of more selective and better-tolerated antihypertensive agents, the use of pempidine has declined.
Side effects[edit | edit source]
The use of pempidine can lead to several side effects due to its non-selective action on the autonomic nervous system. Common side effects include dry mouth, constipation, urinary retention, and blurred vision. These side effects are a result of the blockade of parasympathetic ganglia.
History[edit | edit source]
Pempidine was developed in the mid-20th century as part of the search for effective antihypertensive agents. It was one of the first drugs to demonstrate the potential of ganglionic blockade in the management of high blood pressure. However, its use has largely been replaced by more modern medications with fewer side effects.
Related pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD