Pericentric inversion

Pericentric inversion is a type of chromosomal inversion that involves a change in the orientation of the genetic material within a chromosome. This change occurs when a section of a chromosome that includes the centromere is reversed, resulting in a flipped sequence of genes.

Overview

In a pericentric inversion, a segment of a chromosome, including the centromere, undergoes a two-break event which causes the segment to rotate 180 degrees before reinserting. This results in a change in the order of the genes on the chromosome, but does not involve a change in the total amount of genetic material.

Causes

Pericentric inversions can occur spontaneously during the formation of gametes or can be induced by exposure to certain chemicals or radiation. They can also be inherited from a parent who carries the inversion.

Effects

The effects of a pericentric inversion can vary greatly depending on the specific genes involved in the inversion. In some cases, the inversion may have no noticeable effect on the individual's health or development. However, in other cases, the inversion can lead to genetic disorders or can increase the risk of miscarriage or infertility.

Diagnosis and Treatment

Pericentric inversions can be diagnosed through genetic testing, including karyotyping and fluorescence in situ hybridization (FISH). Treatment for conditions caused by pericentric inversions typically involves managing the symptoms of the condition, as there is currently no way to reverse the inversion itself.

See Also

• Paracentric inversion
• Chromosomal inversion
• Genetic disorder
• Karyotype