Perinuclear space

Perinuclear space is a region of the cell that is located between the inner nuclear membrane and the outer nuclear membrane. This space is a key component of the nuclear envelope, which encloses the nucleus in eukaryotic cells.

Structure

The perinuclear space is approximately 20-40 nanometers wide and is continuous with the lumen of the endoplasmic reticulum. It is filled with a gel-like substance that is similar in composition to the lumen of the endoplasmic reticulum. The inner and outer nuclear membranes that define the perinuclear space are part of the nuclear envelope, which separates the contents of the nucleus from the cytoplasm.

Function

The perinuclear space plays a crucial role in the transport of molecules between the nucleus and the cytoplasm. It is involved in the selective transport of proteins and RNA molecules through nuclear pore complexes, which are embedded in the nuclear envelope. The perinuclear space also plays a role in the assembly and disassembly of the nuclear envelope during cell division.

Clinical significance

Alterations in the structure or function of the perinuclear space can lead to various diseases. For example, mutations in genes encoding proteins of the nuclear envelope can cause nuclear envelopathies, a group of rare genetic disorders that can affect various tissues and organs. In addition, changes in the perinuclear space have been associated with cancer and aging.

See also

• Nuclear envelope
• Nuclear pore
• Endoplasmic reticulum
• Cell nucleus