Phage P22 tailspike protein

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TailspikeProtein

Phage P22 Tailspike Protein

The Phage P22 tailspike protein is a crucial component of the bacteriophage P22, a virus that infects the bacterium Salmonella enterica. The tailspike protein plays a significant role in the viral infection process by recognizing and binding to specific receptors on the surface of the bacterial cell.

Structure[edit | edit source]

The Phage P22 tailspike protein is a trimeric protein composed of three identical subunits. Each subunit consists of distinct domains that are responsible for different functions. The protein has a long, fibrous structure with a receptor-binding domain at one end and a catalytic domain at the other end.

Function[edit | edit source]

The primary function of the Phage P22 tailspike protein is to recognize and bind to the O-antigen polysaccharides present on the surface of Salmonella enterica cells. This binding specificity allows the bacteriophage to attach to the bacterial cell and initiate the infection process. Additionally, the catalytic domain of the tailspike protein has enzymatic activity that degrades the O-antigen, facilitating the release of the viral genetic material into the host cell.

Role in Infection[edit | edit source]

During the infection process, the Phage P22 tailspike protein plays a critical role in the initial attachment of the bacteriophage to the bacterial cell. By binding to the O-antigen receptors, the tailspike protein helps the virus to specifically target Salmonella enterica cells for infection. Once attached, the enzymatic activity of the tailspike protein aids in the degradation of the bacterial cell wall, allowing the viral genetic material to enter the host cell and initiate the replication cycle.

Importance[edit | edit source]

The Phage P22 tailspike protein is essential for the successful infection of Salmonella enterica by the bacteriophage P22. Its specific binding affinity for the O-antigen receptors on the bacterial cell surface ensures the efficient targeting of host cells for viral replication. Additionally, the enzymatic activity of the tailspike protein contributes to the breakdown of the bacterial cell wall, facilitating the release of viral progeny and the spread of infection.

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Contributors: Prab R. Tumpati, MD