Deiters' cells

Outer hair cell and Deiter's cell

Cochlea-crosssection

Deiters' cells, also known as outer phalangeal cells, are a type of supporting cell found in the organ of Corti, which is part of the cochlea in the inner ear. These cells play a crucial role in the function of the auditory system, particularly in the mechanics of hearing. Deiters' cells are named after the German anatomist Otto Deiters, who first described them.

Structure

Deiters' cells are characterized by their unique structure, which includes a cell body from which extend several processes. One of these processes anchors to the basilar membrane, providing structural support to the organ of Corti. The other processes extend upwards to support the outer hair cells, which are critical for the amplification and fine-tuning of sound vibrations. The nucleus of a Deiters' cell is located in the lower part of the cell body, closer to the basilar membrane.

Function

The primary function of Deiters' cells is to provide structural support to the outer hair cells within the organ of Corti. By anchoring the hair cells, they maintain the precise organization necessary for the hair cells to function effectively in sound transduction. Additionally, Deiters' cells are involved in the electrolyte balance within the endolymph, the fluid filling the space of the cochlear duct. This regulation of electrolyte balance is crucial for maintaining the endocochlear potential, which is necessary for the hair cells to transduce sound vibrations into electrical signals.

Deiters' cells also play a role in the auditory system's ability to adapt to different listening conditions. They are thought to participate in the mechanical tuning of the cochlea, helping to refine the sensitivity and frequency selectivity of hearing.

Clinical Significance

Damage or dysfunction of Deiters' cells can lead to hearing loss, as their support is crucial for the proper functioning of the outer hair cells. Conditions such as otosclerosis, noise-induced hearing loss, and certain genetic disorders can affect the health and function of Deiters' cells, leading to impaired hearing.

Research

Ongoing research into Deiters' cells focuses on understanding their precise role in hearing and how they interact with other cells within the organ of Corti. Studies are also exploring potential therapeutic strategies for protecting or repairing damaged Deiters' cells as a means to treat or prevent hearing loss.