Phenelzine

From WikiMD's Wellness Encyclopedia

(Redirected from Phenylethylhydrazine)

Phenelzine


Phenelzine is a monoamine oxidase inhibitor (MAOI) that is used as an antidepressant and anxiolytic in the treatment of mood disorders and anxiety disorders, and for some types of chronic pain.

Pharmacology[edit | edit source]

Phenelzine acts by irreversibly inhibiting the action of monoamine oxidase (MAO), an enzyme that breaks down monoamines in the body. This results in an increase in the concentration of these neurotransmitters in the brain, which can improve symptoms of depression and anxiety. Phenelzine is a non-selective and irreversible inhibitor of the enzyme monoamine oxidase (MAO). This means it inhibits both isoforms of the enzyme, MAO-A and MAO-B, and does not dissociate from them after binding (i.e., the inhibition is irreversible).

Clinical use[edit | edit source]

Phenelzine is used primarily in the treatment of major depressive disorder (MDD). Patients with depressive symptomatology characterized as "atypical", "nonendogenous", and/or "neurotic" respond particularly well to phenelzine. The medication is also effective in patients with panic disorder and bipolar depression.

Side effects[edit | edit source]

Common side effects of phenelzine may include dizziness, blurred vision, dry mouth, and constipation. More serious side effects may include difficulty urinating, swelling, and a rapid or irregular heartbeat.

Interactions[edit | edit source]

Phenelzine has a number of drug interactions. Most importantly, combining phenelzine with certain other substances can lead to serious and potentially fatal reactions such as serotonin syndrome or hypertensive crisis.

See also[edit | edit source]

References[edit | edit source]


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD