Phosphoribosyl-N-formylglycineamide
Overview of Phosphoribosyl-N-formylglycineamide
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Phosphoribosyl-N-formylglycineamide (FGAR) is an intermediate in the purine biosynthesis pathway. It is formed from phosphoribosylamine and formylglycineamide ribonucleotide (FGAR) in a reaction catalyzed by the enzyme phosphoribosylformylglycineamide synthetase.
Role in Purine Biosynthesis[edit | edit source]
FGAR plays a crucial role in the de novo synthesis of purine nucleotides. The conversion of FGAR to phosphoribosylformylglycinamidine (FGAM) is a key step in the pathway, which eventually leads to the formation of inosine monophosphate (IMP), a precursor to both adenosine monophosphate (AMP) and guanosine monophosphate (GMP).
Enzymatic Reaction[edit | edit source]
The enzyme phosphoribosylformylglycineamide synthetase catalyzes the formation of FGAR from phosphoribosylamine and formylglycineamide ribonucleotide. This reaction is ATP-dependent and involves the transfer of a formyl group to the amino group of phosphoribosylamine.
Clinical Significance[edit | edit source]
Disruptions in the purine biosynthesis pathway, including the steps involving FGAR, can lead to various metabolic disorders. For example, deficiencies in enzymes of this pathway can result in gout or immunodeficiency disorders.
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Contributors: Prab R. Tumpati, MD
