Piperaquine

Piperaquine is an antimalarial drug that is often used in combination with other drugs, such as artemisinin, to treat malaria. It is a bisquinoline, part of a family of drugs that also includes chloroquine and quinine, which have been used for many years to prevent and treat malaria.

History

Piperaquine was first synthesized in the 1960s and was widely used in China and Cambodia during the 1970s and 1980s as a first-line treatment for malaria. However, its use declined in the 1990s due to the emergence of resistance. In recent years, it has been reintroduced in combination with artemisinin, a potent and rapidly acting antimalarial drug.

Mechanism of Action

Piperaquine works by interfering with the parasite's ability to break down and digest hemoglobin. This leads to the accumulation of toxic heme, which kills the parasite. The exact mechanism of action is not fully understood, but it is thought to involve inhibiting the formation of hemozoin, a substance produced by the parasite to detoxify heme.

Use in Combination Therapy

The combination of piperaquine and artemisinin, known as artemisinin-based combination therapy (ACT), is currently recommended by the World Health Organization (WHO) as a first-line treatment for uncomplicated Plasmodium falciparum malaria. ACTs are highly effective and have contributed significantly to the reduction of malaria cases and deaths in recent years.

Side Effects

Like all medicines, piperaquine can cause side effects, although not everybody gets them. Common side effects include headache, dizziness, loss of appetite, nausea, vomiting, abdominal pain, and rash. Serious side effects are rare but can include changes in heart rhythm, liver problems, and severe allergic reactions.

Resistance

Resistance to piperaquine has been reported in some areas, particularly in Southeast Asia. This is a major concern as it threatens the effectiveness of ACTs. Ongoing surveillance and research are needed to monitor the situation and develop new treatments.

See Also

• Antimalarial medication
• Malaria
• Artemisinin
• Chloroquine
• Quinine

Piperaquine Resources
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