Piriprost

Piriprost

Piriprost is a synthetic compound that belongs to the class of drugs known as prostaglandin analogs. It is primarily used in the treatment of certain types of glaucoma and ocular hypertension. Piriprost works by reducing intraocular pressure, which is a major risk factor for glaucoma.

Pharmacology

Piriprost is a prostaglandin analog, which means it mimics the action of naturally occurring prostaglandins in the body. Prostaglandins are lipid compounds that have diverse hormone-like effects in animals. In the eye, prostaglandins increase the outflow of aqueous humor, the fluid in the eye, thereby reducing intraocular pressure.

Mechanism of Action

Piriprost binds to the prostaglandin F receptor (FP receptor) in the eye. This binding activates a series of biochemical pathways that lead to the remodeling of the extracellular matrix in the trabecular meshwork and uveoscleral pathways, enhancing the outflow of aqueous humor. The reduction in intraocular pressure helps prevent damage to the optic nerve, which is crucial in managing glaucoma.

Pharmacokinetics

After topical administration to the eye, piriprost is absorbed into the cornea and reaches its site of action. It is metabolized in the eye and systemic circulation, with its metabolites being excreted primarily through the kidneys. The half-life of piriprost in ocular tissues is approximately 4 to 6 hours.

Clinical Uses

Piriprost is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It is often prescribed when other medications, such as beta-blockers or carbonic anhydrase inhibitors, are insufficient or contraindicated.

Side Effects

Common side effects of piriprost include:

• Eye irritation or discomfort
• Conjunctival hyperemia (redness of the eye)
• Changes in eyelash growth
• Darkening of the iris

Less common but serious side effects may include:

• Macular edema
• Uveitis

Patients are advised to report any severe or persistent side effects to their healthcare provider.

Contraindications

Piriprost is contraindicated in patients with known hypersensitivity to prostaglandin analogs. Caution is advised in patients with a history of intraocular inflammation or macular edema.

Interactions

Piriprost may interact with other ocular medications. It is important to inform healthcare providers of all medications being used to avoid potential interactions.

Also see

• Glaucoma
• Prostaglandin analogs
• Intraocular pressure
• Ocular hypertension