Piromelatine

Piromelatine is a sedative and anxiolytic drug that is used in the treatment of insomnia. It is a melatonin receptor agonist and serotonin receptor antagonist, which means it works by affecting certain chemicals in the brain that help promote sleep.

Pharmacology

Piromelatine has a unique mechanism of action, acting as a melatonin receptor agonist and a serotonin receptor antagonist. This dual action is thought to contribute to its effectiveness in treating insomnia.

Melatonin receptor agonism

Piromelatine binds to and activates the melatonin receptor, a protein in the brain that is involved in regulating the sleep-wake cycle. By activating this receptor, piromelatine can help to promote sleep.

Serotonin receptor antagonism

In addition to its action on the melatonin receptor, piromelatine also acts as an antagonist at certain serotonin receptors. This means it blocks the action of serotonin, a neurotransmitter that can promote wakefulness.

Clinical use

Piromelatine is used in the treatment of insomnia, a sleep disorder characterized by difficulty falling asleep or staying asleep. It is typically used when other treatments have not been effective.

Side effects

Like all medications, piromelatine can cause side effects. These may include dizziness, headache, and daytime drowsiness. If these side effects persist or worsen, patients should contact their healthcare provider.

See also

• Melatonin receptor agonist
• Serotonin receptor antagonist
• Insomnia

Piromelatine Resources
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