Pleomorphism (cytology)
Pleomorphism (cytology)
Pleomorphism in cytology refers to the variability in size, shape, and arrangement of cells and/or their nuclei. This term is often used in the context of cancer cells, which frequently exhibit pleomorphism. The degree of pleomorphism can be an indicator of the aggressiveness of a tumor.
Overview[edit | edit source]
Pleomorphism is a common feature of malignant cells, including those found in carcinomas, sarcomas, and lymphomas. It is one of the criteria used by pathologists to determine the grade of a tumor, with more pleomorphic tumors generally being of a higher grade.
Mechanisms[edit | edit source]
The mechanisms underlying pleomorphism in cancer cells are not fully understood. However, it is thought to be related to genetic instability, which is a hallmark of cancer. Genetic instability can lead to changes in the size and shape of the nucleus, as well as the overall cell.
Clinical significance[edit | edit source]
The degree of pleomorphism can have clinical implications. For example, tumors with a high degree of pleomorphism are generally more aggressive and have a poorer prognosis. In addition, pleomorphism can be used to differentiate between different types of tumors. For example, adenocarcinomas are typically more pleomorphic than squamous cell carcinomas.
See also[edit | edit source]
References[edit | edit source]
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