Polyaminopropyl biguanide

Polyaminopropyl biguanide

Polyaminopropyl biguanide (PAPB) is a polymeric biguanide with a broad spectrum of antimicrobial activity. It is used in various applications, including as a disinfectant in contact lens solutions and as a preservative in cosmetics.

Chemistry

Polyaminopropyl biguanide is a polymer of propyl biguanide units linked by amine groups. The biguanide units confer antimicrobial activity, while the propyl groups provide hydrophobicity, which enhances the compound's ability to penetrate microbial cell walls.

Antimicrobial activity

Polyaminopropyl biguanide has a broad spectrum of antimicrobial activity. It is effective against a wide range of bacteria, fungi, and protozoa. Its mechanism of action involves disruption of the microbial cell membrane, leading to leakage of cellular contents and cell death.

Applications

Contact lens solutions

Polyaminopropyl biguanide is used as a disinfectant in contact lens solutions. It is effective in killing bacteria, fungi, and protozoa that can contaminate contact lenses and cause eye infections.

Cosmetics

Polyaminopropyl biguanide is used as a preservative in cosmetics. It prevents the growth of bacteria and fungi, thereby prolonging the shelf life of cosmetic products.

Safety

Polyaminopropyl biguanide is generally considered safe for use in contact lens solutions and cosmetics. However, some people may experience eye irritation or allergic reactions to the compound.

See also

• Biguanide
• Antimicrobial
• Disinfectant
• Preservative