Polycystin 2
Polycystin-2[edit | edit source]
Polycystin-2 is a protein encoded by the PKD2 gene in humans. It is a member of the polycystin family of proteins and plays a crucial role in the function of primary cilia and the regulation of calcium ion channels. Polycystin-2 is involved in the development and maintenance of renal tubules and is associated with autosomal dominant polycystic kidney disease (ADPKD).
Structure[edit | edit source]
Polycystin-2 is an integral membrane protein that functions as a non-selective cation channel. It is composed of multiple transmembrane domains and has both intracellular and extracellular regions. The protein forms a complex with polycystin-1, encoded by the PKD1 gene, to mediate its functions in the cell.
Function[edit | edit source]
Polycystin-2 is primarily located in the endoplasmic reticulum and the plasma membrane, where it acts as a calcium-permeable channel. It is involved in the regulation of intracellular calcium levels, which is essential for various cellular processes, including cell proliferation, apoptosis, and cell differentiation.
Role in Disease[edit | edit source]
Mutations in the PKD2 gene can lead to autosomal dominant polycystic kidney disease, a genetic disorder characterized by the formation of numerous cysts in the kidneys. These cysts can lead to kidney failure and other complications. The interaction between polycystin-1 and polycystin-2 is critical for normal kidney function, and disruptions in this interaction can contribute to disease pathogenesis.
Related Proteins[edit | edit source]
Polycystin-2 is part of a larger family of polycystin proteins, which includes polycystin-1 and other related proteins. These proteins share structural similarities and are involved in similar cellular pathways.
Research and Therapeutic Implications[edit | edit source]
Understanding the function and regulation of polycystin-2 is important for developing potential therapies for ADPKD. Research is ongoing to identify compounds that can modulate the activity of polycystin-2 and restore normal cellular function in affected individuals.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
