Polymegethism

Polymegethism is a medical condition characterized by an abnormal variation in the size of corneal endothelial cells. It is often associated with other corneal diseases and conditions, such as Fuchs' dystrophy and corneal edema.

Overview

Corneal endothelial cells are essential for maintaining the transparency of the cornea. They function as a barrier and pump between the cornea and the aqueous humor, controlling corneal hydration by facilitating fluid and solute transport. In polymegethism, there is an increased variation in the size of these cells, which can lead to corneal decompensation and vision loss.

Causes

Polymegethism is often associated with aging, contact lens wear, and corneal diseases such as Fuchs' dystrophy. It can also occur as a result of corneal surgery or trauma.

Diagnosis

The diagnosis of polymegethism is typically made using a non-invasive imaging technique called specular microscopy. This allows for the visualization and measurement of corneal endothelial cells, enabling the detection of abnormal cell size variation.

Treatment

Treatment of polymegethism is primarily focused on managing the underlying cause. This may involve discontinuing contact lens wear, treating associated corneal diseases, or in severe cases, undergoing corneal transplantation.

See also

• Corneal endothelium
• Fuchs' dystrophy
• Specular microscopy