Ponsegromab

Synonyms

Ponsegromab, PF 06946860, PF-06946860, PF06946860, PONSEGROMAB

Thesaurus

A monoclonal antibody directed against the human growth differentiation factor 15 (GDF15; MIC-1), with potential anti-cachexia activity. Upon administration, ponsegromab targets and binds to GDF15, thereby preventing the binding of GDF15 to its receptor glial-cell-derived neurotrophic factor (GDNF) family receptor alpha-like (GFRAL) and blocking GDF15/GFRAL-mediated signaling. This may abrogate loss of appetite and uncontrolled weight loss associated with high serum levels of GDF15. GDF15, a stress response cytokine and divergent member of the transforming growth factor beta (TGF-beta) superfamily, plays a key role in the regulation of body weight through central mechanisms. High GDF15 plasma levels, as seen in individuals with advanced cancers, are associated with loss of body mass. Ponsegromab, Pharmacologic Substance

• NCI Thesaurus (external)

C20401.

This concise article on Ponsegromab incorporates public domain text from the US National Library of Medicine.

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