Pospiviroidae

From WikiMD's Wellness Encyclopedia

Pospiviroidae is a family of viroids, which are small, circular RNA molecules that are capable of autonomous replication. The family is named after the type species, Potato spindle tuber viroid (PSTVd), and includes several other important plant pathogens.

Characteristics[edit | edit source]

Members of the Pospiviroidae family are characterized by their small size, typically ranging from 246 to 401 nucleotides in length. They have a rod-like secondary structure with a central conserved region (CCR), which is important for replication. The RNA genome does not code for any proteins, but instead relies on host enzymes for replication and movement within the plant.

Replication[edit | edit source]

Pospiviroidae replicate in the nucleus of infected cells using a rolling-circle mechanism. This involves the synthesis of a multimeric RNA strand, which is then cleaved and ligated to form unit-length circular molecules. The exact details of this process, including the enzymes involved, are not fully understood and are the subject of ongoing research.

Pathogenicity[edit | edit source]

Pospiviroidae are responsible for a number of plant diseases, including potato spindle tuber disease, chrysanthemum stunt disease, and tomato chlorotic dwarf disease. The symptoms vary depending on the host plant and the specific viroid, but can include stunting, leaf curling, and reduced yield. The mechanisms by which Pospiviroidae cause disease are not fully understood, but may involve interference with host gene expression.

Control[edit | edit source]

Control of Pospiviroidae diseases is challenging due to the lack of effective treatments. Current strategies focus on prevention, including the use of disease-free planting material and quarantine measures to prevent the spread of infected material. Research is ongoing to develop new control methods, including the use of RNA interference technology.

See also[edit | edit source]

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Contributors: Prab R. Tumpati, MD