Potentiation

Potentiation is a pharmacological concept where the effect of one drug is increased by the presence of another drug. It is a form of drug interaction that can be used therapeutically to increase the efficacy of drugs, but can also lead to adverse effects if not managed correctly.

Mechanism of Action

Potentiation occurs when one drug enhances the effect of another. This can occur through several mechanisms, including enzyme inhibition, pharmacokinetic interactions, and pharmacodynamic interactions. Enzyme inhibition can increase the concentration of a drug in the body by reducing its metabolism, leading to an increased effect. Pharmacokinetic interactions can alter the absorption, distribution, metabolism, or excretion of a drug, leading to an increased effect. Pharmacodynamic interactions can enhance the effect of a drug at its site of action.

Therapeutic Use

Potentiation can be used therapeutically to increase the efficacy of drugs. For example, the antibiotic amoxicillin is often given with the beta-lactamase inhibitor clavulanic acid to potentiate its effect against bacteria that produce beta-lactamase, an enzyme that degrades amoxicillin.

Adverse Effects

While potentiation can be beneficial, it can also lead to adverse effects if not managed correctly. For example, the potentiation of opioid drugs by benzodiazepines can lead to respiratory depression, a potentially fatal condition. Therefore, it is important for healthcare providers to be aware of potential drug interactions and to monitor patients closely when potentiation is likely to occur.

See Also

• Synergism (pharmacology)
• Antagonism (pharmacology)
• Drug interaction

Potentiation Resources
Latest articles Most recent articles Ongoing trials	Wikipedia