Benzylpenicilloyl polylysine

Benzylpenicilloyl polylysine (also known as Pre-Pen) is a diagnostic agent used in skin testing to evaluate sensitization to penicillin in humans. It is a major determinant of penicillin allergy and is used to predict an allergic response to penicillin therapy.

History

The development of benzylpenicilloyl polylysine was a significant advancement in the field of allergy and immunology. It was first introduced in the 1960s as a diagnostic tool for penicillin allergy.

Structure and Properties

Benzylpenicilloyl polylysine is a large, water-soluble molecule. It is composed of a benzylpenicilloyl group attached to a polylysine backbone. The benzylpenicilloyl group is the major determinant for penicillin allergy, while the polylysine backbone provides the molecule with its water-soluble properties.

Use in Allergy Testing

Benzylpenicilloyl polylysine is used in skin testing to evaluate sensitization to penicillin. The test is performed by injecting a small amount of the substance under the skin and observing for a reaction. A positive reaction indicates a high likelihood of penicillin allergy.

Safety and Efficacy

Benzylpenicilloyl polylysine has been shown to be safe and effective in predicting penicillin allergy. However, like all diagnostic tests, it is not 100% accurate and should be used in conjunction with a thorough medical history and other diagnostic tools.

See Also

• Penicillin allergy
• Skin test
• Immunology