Propafenone hydrochloride

Propafenone Hydrochloride is a Class IC antiarrhythmic agent used in the treatment of cardiac arrhythmia. It is a synthetic compound with local anesthetic effects and is often used in the treatment of both supraventricular and ventricular arrhythmias.

Pharmacology

Propafenone hydrochloride works by blocking the fast inward sodium channel, which is responsible for the rapid depolarization phase of the action potential in cardiac muscle. This results in a decrease in the rate of electrical conduction through the heart, thereby restoring normal rhythm.

Clinical Use

Propafenone hydrochloride is used in the treatment of a variety of cardiac arrhythmias, including atrial fibrillation, atrial flutter, and ventricular tachycardia. It is also used in the prevention of recurrent paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation in patients without structural heart disease.

Side Effects

Common side effects of propafenone hydrochloride include dizziness, nausea, vomiting, and taste disturbances. Serious side effects can include proarrhythmia, a condition where the drug can cause new or worsening arrhythmias.

Contraindications

Propafenone hydrochloride is contraindicated in patients with cardiogenic shock, sinus node dysfunction, and bradycardia. It should also be avoided in patients with a history of heart failure or myocardial infarction.

Drug Interactions

Propafenone hydrochloride can interact with a number of other medications, including beta blockers, calcium channel blockers, and digoxin. These interactions can lead to changes in the effectiveness of the medications or increase the risk of side effects.

See Also

• Antiarrhythmic agent
• Cardiac arrhythmia
• Atrial fibrillation
• Ventricular tachycardia