Prorenin receptor

Prorenin receptor is a protein that in humans is encoded by the ATP6AP2 gene. It is a component of the renin-angiotensin system, which regulates blood pressure and fluid balance in the body. The prorenin receptor binds both renin and prorenin, activating them and contributing to the generation of angiotensin, a potent vasoconstrictor.

Function

The prorenin receptor is a transmembrane protein that binds prorenin and renin, leading to their activation and the subsequent production of angiotensin. This process is crucial in the regulation of blood pressure and fluid balance. The receptor is also involved in Wnt signaling pathway, which plays a role in tissue development and repair.

Clinical significance

Mutations in the ATP6AP2 gene that encodes the prorenin receptor can lead to a variety of health conditions. These include X-linked intellectual disability, Parkinson's disease, and Alzheimer's disease. In addition, overexpression of the prorenin receptor has been associated with hypertension and kidney disease.

Research

Research into the prorenin receptor is ongoing, with studies focusing on its role in health and disease, as well as its potential as a therapeutic target for conditions such as hypertension and kidney disease.

See also

• Renin-angiotensin system
• Renin
• Prorenin
• Angiotensin
• ATP6AP2