Prostacyclin synthase
Prostacyclin synthase is an enzyme that in humans is encoded by the PTGIS gene. This enzyme belongs to the family of cytochrome P450 enzymes. It plays a crucial role in the biosynthesis of prostacyclin, a potent vasodilator and inhibitor of platelet aggregation.
Function[edit | edit source]
Prostacyclin synthase converts prostaglandin H2 (PGH2) to prostacyclin (PGI2). This reaction is a part of the eicosanoid synthesis pathway, which is essential for the production of various bioactive lipids that regulate a wide range of physiological processes, including inflammation, blood flow, and platelet function.
Structure[edit | edit source]
The prostacyclin synthase enzyme is a monomer with a molecular weight of approximately 55 kDa. It contains a heme prosthetic group, which is involved in the enzyme's catalytic activity.
Clinical significance[edit | edit source]
Alterations in prostacyclin synthase activity have been associated with various diseases, including cardiovascular disease, pulmonary hypertension, and cancer. In particular, decreased prostacyclin production due to reduced prostacyclin synthase activity is a common feature of atherosclerosis and thrombosis.
See also[edit | edit source]
References[edit | edit source]
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