Prostaglandin D2 receptor 2

Prostaglandin D2 receptor 2 (DP2), also known as G-protein coupled receptor 44 (GPR44), is a protein that in humans is encoded by the PTGDR2 gene. DP2 is a member of the G protein-coupled receptor family and is a receptor for prostaglandin D2 (PGD2).

Function

The primary function of DP2 is to bind with PGD2, a lipid compound derived from fatty acids that plays a key role in mediating inflammation and allergic responses. When PGD2 binds to DP2, it triggers a cascade of intracellular events that lead to the physiological effects of PGD2, such as bronchoconstriction, vasodilation, and inhibition of platelet aggregation.

Clinical significance

DP2 has been implicated in a variety of diseases and conditions, particularly those involving inflammation and the immune system. These include asthma, allergic rhinitis, and atopic dermatitis. Inhibitors of DP2, such as fevipiprant and setipiprant, are currently being investigated as potential treatments for these conditions.

Pharmacology

DP2 is the target of several drugs currently in development for the treatment of asthma and other inflammatory diseases. These drugs, known as DP2 antagonists, work by blocking the action of PGD2 on the receptor, thereby reducing inflammation and allergic responses.

See also

• Prostaglandin D2 receptor 1
• Prostaglandin receptors
• G protein-coupled receptor

References

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