R-flurbiprofen

R-flurbiprofen is an enantiomer of the nonsteroidal anti-inflammatory drug (NSAID) flurbiprofen. It is also known as R(-)-flurbiprofen or Flurbiprofen axetil.

Chemistry

R-flurbiprofen is a chiral molecule, meaning it has a non-superimposable mirror image. The "R" in its name refers to the rectus configuration of the molecule, as opposed to the "S" or sinister configuration. This is a common naming convention in stereochemistry, a branch of chemistry that studies the spatial arrangement of atoms in molecules.

Pharmacology

R-flurbiprofen is a cyclooxygenase inhibitor, specifically a COX-2 inhibitor. This means it works by blocking the enzyme cyclooxygenase, which is involved in the production of prostaglandins, substances in the body that cause inflammation, pain, and fever. By inhibiting this enzyme, R-flurbiprofen can reduce these symptoms.

Clinical Use

R-flurbiprofen is used in the treatment of various conditions that cause pain and inflammation, such as rheumatoid arthritis and osteoarthritis. It is also used in the management of acute pain and to reduce fever.

Side Effects

Like other NSAIDs, R-flurbiprofen can cause a range of side effects. These can include gastrointestinal problems such as stomach pain, heartburn, and ulcers, as well as more serious cardiovascular issues like heart attack and stroke. It can also cause kidney problems, particularly in long-term use.

Research

Research is ongoing into the potential use of R-flurbiprofen in the treatment of Alzheimer's disease. Some studies suggest that it may help to reduce the production of beta-amyloid, a protein that forms plaques in the brains of Alzheimer's patients.

See Also

• Nonsteroidal anti-inflammatory drug
• Flurbiprofen
• Cyclooxygenase
• Alzheimer's disease