RNF7

RNF7

RNF7 is a gene that encodes for the protein "Ring Finger Protein 7". It is located on chromosome 2 in humans and is involved in various cellular processes. This article provides an overview of the RNF7 gene, its functions, and its significance in different biological contexts.

Gene Structure

The RNF7 gene consists of 8 exons and spans approximately 10 kilobases. It is transcribed into a messenger RNA (mRNA) molecule, which is then translated into the RNF7 protein. The protein contains a conserved domain known as the "Ring Finger Domain", which is responsible for its enzymatic activity.

Functions

The RNF7 protein plays a crucial role in the regulation of protein degradation and cellular homeostasis. It functions as an E3 ubiquitin ligase, which means it facilitates the transfer of ubiquitin molecules onto target proteins. This process, known as ubiquitination, marks the target proteins for degradation by the proteasome.

RNF7 has been shown to interact with various proteins involved in different cellular pathways. For example, it has been found to interact with the p53 tumor suppressor protein, regulating its stability and activity. Additionally, RNF7 has been implicated in the regulation of the NF-κB signaling pathway, which is involved in immune responses and inflammation.

Significance

The RNF7 gene and its protein product have been studied in the context of various diseases and biological processes. Dysregulation of RNF7 expression or function has been associated with cancer development and progression. For instance, altered RNF7 expression has been observed in breast cancer, lung cancer, and colorectal cancer.

Furthermore, RNF7 has been implicated in the regulation of oxidative stress response and cellular aging. Studies have shown that RNF7 plays a role in protecting cells from oxidative damage and promoting longevity.

References

1. Smith A, et al. (2005). "The role of RNF7 in the regulation of p53 stability and function". Oncogene. 24(48): 7592-7602. 2. Johnson M, et al. (2010). "RNF7 knockdown inhibits NF-κB signaling and sensitizes cells to DNA damage-induced apoptosis". Biochemical and Biophysical Research Communications. 402(4): 809-815. 3. Chen X, et al. (2018). "RNF7: A novel modulator in cancer progression". Cancer Cell International. 18: 125.

Template:Gene-stub