RTI-120

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RTI-120 is a psychoactive drug and research chemical that belongs to the phenyltropane class of stimulants. It is primarily used in scientific research and has not been approved for medical use. RTI-120 is structurally similar to cocaine, but with a higher affinity for the dopamine transporter and a lower affinity for the serotonin transporter and norepinephrine transporter.

Chemistry[edit | edit source]

RTI-120 is a phenyltropane-based compound. Phenyltropanes are a family of drugs that have a tropane core structure, which is a bicyclic structure consisting of a seven-membered ring fused to a five-membered nitrogen-containing ring. The phenyltropane structure is similar to that of cocaine, but with modifications that alter its pharmacological properties.

Pharmacology[edit | edit source]

RTI-120 acts as a potent dopamine reuptake inhibitor, meaning it blocks the reuptake of dopamine into neurons, thereby increasing the amount of dopamine available in the brain. This results in increased stimulation of dopamine receptors, which is associated with feelings of pleasure and reward. Unlike cocaine, RTI-120 has a lower affinity for the serotonin and norepinephrine transporters, making it more selective for the dopamine transporter.

Research Use[edit | edit source]

As a research chemical, RTI-120 is used in scientific studies to investigate the role of the dopamine transporter in various processes, including drug addiction and neurological disorders. It is not approved for medical use and is not available for prescription.

Safety and Legal Status[edit | edit source]

The safety profile of RTI-120 is not well-studied, as it is not intended for human consumption. Its legal status varies by country, and it may be controlled under analogue laws in some jurisdictions.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD