Racecadotril

Racecadotril is a medication primarily used in the treatment of acute diarrhea. It is an antidiarrheal agent that works by reducing the secretion of water and electrolytes into the intestine. Racecadotril is marketed under various brand names across the world, including Hidrasec and Acetorphan.

Mechanism of Action

Racecadotril exerts its antidiarrheal effect by acting as a prodrug of thiorphan, which is an enzyme inhibitor that blocks the action of enkephalinase. Enkephalinase is an enzyme that breaks down enkephalins, which are natural substances in the body that bind to opioid receptors and inhibit the secretion of water and electrolytes into the intestine. By inhibiting enkephalinase, racecadotril increases the concentration of enkephalins, thereby reducing the secretion of water and electrolytes into the intestine.

Indications

Racecadotril is indicated for the symptomatic treatment of acute diarrhea in adults and children, in conjunction with oral rehydration therapy. It is also used in the management of chronic diarrhea in patients with conditions such as Irritable Bowel Syndrome (IBS) and Crohn's disease.

Side Effects

The most common side effects of racecadotril include headache, rash, and nausea. In rare cases, it can cause severe allergic reactions.

Contraindications

Racecadotril is contraindicated in patients with known hypersensitivity to the drug or any of its components. It should also not be used in patients with severe kidney or liver disease without medical supervision.

Interactions

Racecadotril may interact with other medications, including other antidiarrheal agents, antibiotics, and drugs that affect the nervous system, such as opioids and antidepressants.

Dosage and Administration

The dosage of racecadotril varies depending on the age and weight of the patient, as well as the severity of the diarrhea. It is usually taken orally, three times a day, until the diarrhea stops.

See Also

• Antidiarrheal agents
• Enkephalinase inhibitors
• Acute diarrhea
• Chronic diarrhea