Reductive amination

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Reductive amination is a chemical reaction that involves the conversion of a carbonyl compound (such as an aldehyde or ketone) into an amine via an intermediate imine or iminium ion. This process is widely used in both organic synthesis and industrial applications to form C-N bonds.

Mechanism[edit | edit source]

The reductive amination process typically involves two main steps:

  1. Formation of an imine or iminium ion: The carbonyl compound reacts with an amine to form an imine (R2C=NR') or iminium ion (R2C=NR'2+).
  2. Reduction: The imine or iminium ion is then reduced to form the corresponding amine (R2CH-NR').

The reduction step can be carried out using various reducing agents, such as sodium cyanoborohydride (NaBH3CN), sodium borohydride (NaBH4), or hydrogen in the presence of a catalyst.

Applications[edit | edit source]

Reductive amination is a versatile method for the synthesis of primary, secondary, and tertiary amines. It is commonly used in the pharmaceutical industry for the synthesis of drugs and in the production of fine chemicals. The reaction is also employed in the synthesis of natural products and biologically active compounds.

Advantages[edit | edit source]

Reductive amination offers several advantages:

  • High selectivity and yield
  • Mild reaction conditions
  • Compatibility with a wide range of functional groups

Examples[edit | edit source]

Some notable examples of reductive amination include:

See also[edit | edit source]

References[edit | edit source]

External links[edit | edit source]


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Contributors: Prab R. Tumpati, MD