Resolvin

Resolvin is a type of bioactive metabolite that is derived from omega-3 fatty acids. These metabolites play a crucial role in the resolution phase of an inflammatory response. Resolvins are part of the larger family of Specialized pro-resolving mediators (SPMs), which also includes protectins and maresins.

Production

Resolvins are produced from the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The production process involves several enzymes, including lipoxygenase and cyclooxygenase. The resulting resolvins are classified as either E-series or D-series, depending on whether they were derived from EPA or DHA, respectively.

Function

Resolvins have a variety of functions in the body, but their primary role is in the resolution phase of inflammation. They help to stop the inflammatory response and promote the return of the tissue to its normal state. This is achieved by reducing the production of pro-inflammatory cytokines, inhibiting the migration of neutrophils to the site of inflammation, and promoting the clearance of dead cells and debris.

Clinical significance

Due to their role in inflammation, resolvins have been studied for their potential therapeutic applications. They may be beneficial in conditions characterized by chronic inflammation, such as rheumatoid arthritis, asthma, and atherosclerosis. However, more research is needed to fully understand their potential benefits and risks.

See also

• Specialized pro-resolving mediators
• Inflammation
• Omega-3 fatty acid

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